Hidden in plain sight, an age-old conflict rages on. Supernatural monsters known as "Curses" terrorize humanity from the shadows, and powerful humans known as "Jujutsu" sorcerers use mystical arts to exterminate them. When high school student Yuuji Itadori finds a dried-up finger of the legendary Curse Sukuna Ryoumen, he suddenly finds himself joining this bloody conflict.
Attacked by a Curse attracted to the finger's power, Yuuji makes a reckless decision to protect himself, gaining the power to combat Curses in the process but also unwittingly unleashing the malicious Sukuna into the world once more. Though Yuuji can control and confine Sukuna to his own body, the Jujutsu world classifies Yuuji as a dangerous, high-level Curse who must be exterminated.